Named a National Center of Excellence for Advanced Wound Care Technologies
Drs. Kevin Lam, Ramy Fahim and W. Drew Chapman of Family Foot and Leg Center
239 430 3668
The Use of Amniotic Stem Cells in Wound Healing
Stem cells are a class of undifferentiated or “primitive” cells
that are able to divide and differentiate into specialized cells of the body
such as skin, bone, muscle cells, blood cells, liver cells, and the like. The
two main types are embryonic stem cells and adult stem cells. Embryonic stem
cells are derived from the inner cells mass of blastocysts of pre-implantation
stage embryos. Adult stem cells are less controversial than embryonic stem
cells because their production does not involve the destruction of an embryo.
It is now possible to take stem cells from the amniotic
fluid and reprogram them to a more versatile state akin to embryonic stem
cells. Using stem cells from amniotic fluid overcomes the ethical opposition to
using human embryos as a source of cells.
Amniotic stem cells have a wide range of applications that
can be used in research and treatment. A study confirms that the amniotic fluid
is a good source of stem cells. This is seen to be more acceptable because this
involves no genetic manipulation. Amniotic stem cells can differentiate into
various types such as muscle, skin, bone, cartilage, cardiac tissue, nerves,
and have a great potential in various medical applications.
Wound healing is a major health problem. Chronic wounds such
as a leg ulcer, a foot wound caused by diabetes, and other slow healing wounds
have a biological or physiological cause for not healing. Among diabetics, for
instance, it is estimated that 15 percent of these patients will develop an
open foot sore or diabetic foot ulcer. These chronic wounds have been difficult
Today, the use of stem cell therapy along in combination
with medications and proper wound care can help encourage better wound healing.
Stem cell rich materials injected into the area can allow for effective wound
healing that otherwise can take considerably longer to heal or may not have
healed otherwise. Amniotic stem cell treatments are now revolutionizing chronic
wound treatments. Recent studies show that stem cell therapy can dramatically
improve the condition of chronic and deeper wounds which would otherwise
require more lengthy and expensive rehabilitation.
The healing activity of stem cells is due to their ability
to separate into the different component cells of injured tissues as well as
release growth factors that may encourage the formation of new blood vessels in
the patient. It has been evident that these cells have the ability to multiply,
integrate with the host tissue, and replace the damaged cells. Using amniotic
stem cells in wound healing have sped up the rate of recovery and the results
have been outstanding, saving limbs / lives.
|Post Moh's surgery for skin cancer. Cancer free, now it is toe saving time. High risk for amputation skin cancer skillfully removed by Mohs surgeon now the challenge. Day 0|
|Toe Saving Time after amniotic injection and matrix graft Day 14|
|Toe Saving time Day 21|
|Complete healing at Day 45|
Podiatric Surgeon called for consult for large wound s/p fasciotomy for limb salvage. First Podiatric surgery entails debridement and injection of amniotic tissue injectable graft 1.25 cc x 4 vials at a one to one mixture with lidocaine plain. Injection done at 12,3,6,9 o clock locations.
|Compartment syndrome medial leg day 0 10/26/2012|
|Lateral Leg Day 0 10/26/2012|
|Lateral Leg Wound Day 3 |
|Medial leg day 3|
|Healthy Medial Leg Wound 2 Weeks Later, applied injectible Liquidgen graft ( 1.25ml inject ) and Amniotic Matrix Graft secured with Steristrips. |
|Healing Healthy Medial Leg Granulation just 2 wks after the above picture. |
|Medial Leg Wound Month #2|
|Lateral Leg Wound Month #2 Note Hyper Granulation Tissue|
|Note Tissue Growth into and through the none adherent dressing|
Experience with Amniotic injectable and matrix grafting has been amazing for limb salvage.
Another Limb Saved at the Family Foot and Leg Center, PA.
Besides wounds the injectable graft has been used for none unions as well as aid in reconstructive foot / ankle surgery to help ensure a union in difficult cases.
I did not know much about this treatment and also about this disease. So while searching for these information on this treatment on the internet , I found that if one person who is diagnosed with it get stem cell therapy it might cure their disease.ReplyDelete
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